byten Hoeve, Arne Lucas; Roda, Mojtaba Abdul; Redegeld, Frank; Folkerts, Gert; Blalock, James Edwin; Gaggar, Amit
This article is from Tanaffos , volume 11 . Abstract The present review discusses the role of tri-peptide Proline –Glycine –Proline (PGP) as a potential player, biomarker and therapeutic target in this process. Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153190
byAbdul Roda, Mojtaba; Sadik, Mariam; Gaggar, Amit; Hardison, Matthew T.; Jablonsky, Michael J.; Braber, Saskia; Blalock, James Edwin; Redegeld, Frank A.; Folkerts, Gert; Jackson, Patricia L.
This article is from PLoS ONE , volume 9 . Abstract A novel neutrophil chemoattractant derived from collagen, proline-glycine-proline (PGP), has been recently characterized in chronic obstructive pulmonary disease (COPD). This peptide is derived via the proteolytic activity of matrix metalloproteases (MMP's)-8/9 and PE, enzymes produced by neutrophils and present in COPD serum and sputum. Valproic acid (VPA) is an inhibitor of PE and could possibly have an effect on the severity of chronic... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023971